Size  100ug
Cat code  200395
Species Cross-reactivity  H
Key Application  WB
Host  Mouse
Antibody type  Monoclonal antibody
Purified method  Affinity purified
Isotype  IgG1
Molecular Weight  110kDa
Sensitivity  This antibody detects endogenous levels of ITGB3 and does not cross-react with related proteins.
Immunogen  Purified recombinant human ITGB3 protein fragments expressed in E.coli.
UniProt Number  P05106
GeneBank ID  NM_000212
Subcellular location  Membrane; Single-pass type I membrane protein.
Formulation  Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Altername  BDPLT2;CD 61;CD61;CD61 antigen;GP3A;GPIIIa;GT;HPA 1;HPA 4;Integrin beta 3 (platelet glycoprotein IIIa antigen CD61);Integrin beta chain beta 3;Integrin beta-3;ITB3_HUMAN;ITG B3;ITGB 3;ITGB3;NAIT;Platelet fibrinogen receptor beta subunit;Platelet glycoprotein IIIa;platelet glycoprotein IIIa precursor;Platelet membrane glycoprotein IIIa;PTP;
Gene_symbol  GT; CD61; GP3A; BDPLT2; GPIIIa
Summary  The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
UniPort summary  Function  Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi´s sarcoma lesions.
Application Images :  
Western blot detection of ITGB3 in 15ug & 25ug Leukocyte whole cell lysate(1:1000 diluted).Predicted band size:110KDa.Observed band size:110KDa.