Size  100ug
Cat code  200873
Species Cross-reactivity  H
Key Application  WB
Host  Mouse
Antibody type  Monoclonal antibody
Purified method  
Isotype  IgG2b
Molecular Weight  37kDa
Sensitivity  This antibody detects endogenous levels of IL18BP and does not cross-react with related proteins.
Immunogen  Purified recombinant human IL18BP protein fragments expressed in E.coli.
UniProt Number  O95998
GeneBank ID  NM_001145057
Subcellular location  Secreted
Formulation  ascites
Altername  I18BP_HUMAN;IL-18BP;IL18 BP;IL18 BPa;IL18BP;IL18BPa;Interleukin 18 binding protein;Interleukin-18-binding protein;MC51L 53L 54L homolog gene product;Tadekinig alfa;Tadekinig-alfa.
Gene_symbol  IL18BPa
Summary  The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine,IL18. It binds IL18,prevents the binding of IL18 to its receptor,and thus inhibits IL18-induced IFN-gamma production,resulting in reduced T-helper type 1 immune responses.This protein is constitutively expressed and secreted in mononuclear cells.Elevated level of this protein is detected in the intestinal tissues of patients with Crohn´s disease.Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq,Feb 2011]
UniPort summary  Function  Isoform A binds to IL-18 and inhibits its activity.Functions as an inhibitor of the early TH1 cytokine response.
Application Images :  
Western blot detection of IL18BP antibody in CHO-K1 cells transfected by IL18BP-PDGFR fusion protein and K562 cell lysates using IL18BP antibody (1:400-1:1000 diluted).Predicted band size:37KDa.Observed band size:37/40KDa.