Size  100ul
Cat code  220018
Species Cross-reactivity  H
Key Application  WB
Host  Mouse
Clone Number  3G8-D8-C2
Antibody type  Monoclonal antibody
Purified method  
Isotype  IgG1
Molecular Weight  61kDa
Sensitivity  The antibody detects endogenous level of total hsp60 protein.
Immunogen  Purified recombinant fragment of human HSP60 expressed in E. Coli.
UniProt Number  P10809
GeneBank ID  NM_002156.4
Subcellular location  Mitochondrion matrix.
Formulation  Ascitic fluid containing 0.03% sodium azide.
Altername  60 kDa chaperonin ; 60 kDa heat shock protein mitochondrial ; 60 kDa heat shock protein, mitochondrial ; 60kDa ; cb863 ; CH60_HUMAN ; Chaperonin 60 ; Chaperonin ; Chaperonin, 60-KD ; CPN 60 ; CPN60 ; fa04a05 ; fb22d10 ; fi27b05 ; GROEL ; GroEL Homolog ; GroEL, E. coli, homolog of ; Heat shock 60kD protein 1 (chaperonin) ; Heat shock 60kD protein 1 chaperonin ; heat shock 60kDa protein 1 (chaperonin) ; Heat shock 60kDa protein 1 ; Heat shock protein 1 (chaperonin) ; Heat Shock Protein 60 ; Heat shock protein 65 ; HLD4 ; Hsp 60 ; HSP 65 ; HSP-60 ; HSP60 ; HSP65 ; HSPD 1 ; HSPD1 ; HuCHA60 ; id:ibd2197 ; Mitochondrial matrix protein P1 ; P60 lymphocyte protein ; sb:cb144 ; Short heat shock protein 60 Hsp60s1 ; Spastic paraplegia 13 (autosomal dominant) ; Spastic paraplegia 13 ; SPG 13 ; SPG13 ; wu:fa04a05 ; wu:fb22d10 ; wu:fi04a12 ; wu:fi27b05 ;
Gene_symbol  HLD4; CPN60; GROEL; HSP60; HSP65; SPG13; HSP-60; HuCHA60
Summary  This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]
UniPort summary  Function  Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.
Application Images :  
Western blot detection of HSP60 antibody in Jurkat, HepG2 and Hela cell lysates using HSP60 antibody(dilution 1:500).Predicted band size:61KDa.Observed band size:61KDa.