Size  100ug
Cat code  200471
Species Cross-reactivity  M
Key Application  WB
Host  Mouse
Antibody type  Monoclonal antibody
Purified method  Affinity purified
Isotype  IgG2a
Molecular Weight  190kDa
Sensitivity  This antibody detects endogenous levels ACE(N-terminus) and does not cross-react with related proteins.
Immunogen  Purified recombinant human ACE(N-terminus) protein fragments expressed in E.coli.
UniProt Number  P12821
GeneBank ID  NM_000789
Subcellular location  Angiotensin-converting enzyme, soluble form: Secreted. 
Cell membrane; Single-pass type I membrane protein.
Formulation  Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Altername  DCP; ACE1; DCP1; CD143; MVCD3; MGC26566
Gene_symbol  DCP; ACE1; DCP1; CD143; MVCD3
Summary  This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.
UniPort summary  Function  Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Application Images :  
Western blot detection of ACE(N-terminus) antibody in Mouse kidney cell lysates using ACE(N-terminus) antibody (1:1000 diluted).
Predicted band size:150KDa
Observed band size:190KDa.