Size  100ug
Cat code  200746
Species Cross-reactivity  H,M,R
Key Application  WB
Host  Mouse
Antibody type  Monoclonal antibody
Purified method  Affinity purified
Isotype  IgG2b
Molecular Weight  39kDa
Sensitivity  This antibody detects endogenous levels of MSI1 and does not cross-react with related proteins.
Immunogen  Purified recombinant human MSI1 protein fragments expressed in E.coli.
UniProt Number  O43347
GeneBank ID  NM_002442
Subcellular location  Cytoplasm,Nucleus
Formulation  Purified mouse monoclonal in PBS(pH 7.4) containing  with 0.2% sodium azide, 50% glycerol, 0.1%BSA
Altername  musashi homolog 1 (Drosophila);Musashi (Drosophila) homolog 1;musashi-1;musashi1;RNA-binding protein Musashi homolog 1;Musashi-1;MSI1;
Gene_symbol  null
Summary  This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13.
UniPort summary  Function  RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5´-GUUAGUUAGUUAGUU-3´ and other sequences containing the pattern 5´-[GA]U1-3AGU-3´. May play a role in the proliferation and maintenance of stem cells in the central nervous system
Application Images :  
Western blot detection of MSI1 in U87MG,C6,IMR32,mouse brain&PC12 cell lysates and  using MSI1 antibody (1:1000 diluted). Predicted band size: 39KDa Observed band size:39KDa