Size  100ug
Cat code  200819
Species Cross-reactivity  H
Key Application  WB
Host  Mouse
Antibody type  Monoclonal antibody
Purified method  Affinity purified
Isotype  IgG1
Molecular Weight  76kDa
Sensitivity  This antibody detects endogenous levels of ANXA6 and does not cross-react with related proteins.
Immunogen  Purified recombinant human ANXA6 protein fragments expressed in E.coli.
UniProt Number  P08133
GeneBank ID  NM_001155
Subcellular location  Cytoplasm,Melanosome
Formulation  Purified mouse monoclonal in PBS(pH 7.4) containing  with 0.2% sodium azide, 50% glycerol, 0.1%BSA
Altername  67 kDa calelectrin;Annexin VI;Annexin-6;Calphobindin-II;Chromobindin-20;Lipocortin VI;Protein III;p68;p70;ANXA6
Gene_symbol  X6; CBP68
Summary  Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described.
UniPort summary  Function  May associate with CD21. May regulate the release of Ca2+ from intracellular stores.
Application Images :  
Western blot detection of ANXA6 in T47D,MB4,CEM,MOLT-4 &Jurkat cell lysates and  using ANXA6 antibody (1:1000 diluted). Predicted band size: 76KDa Observed band size:76KDa