Size  100ul
Cat code  200751
Species Cross-reactivity  H
Key Application  WB
Host  Mouse
Clone Number  2A4-H7-C12
Antibody type  Monoclonal antibody
Purified method  Affinity purified
Isotype  IgG1
Molecular Weight  155kDa
Sensitivity  This antibody detects endogenous levels of BAF155 and does not cross-react with related proteins.
Immunogen  Purified recombinant human BAF155 protein fragments expressed in E.coli.
UniProt Number  Q92922
GeneBank ID  NM_003074
Subcellular location  Nucleus.
Formulation  Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Altername  AI115498;BAF 155;BAF155;BRG 1 associated factor 155;BRG1 associated factor 155;BRG1-associated factor 155;Chromatin remodeling complex BAF155 subunit;CRACC 1;CRACC1;Mammalian chromatin remodeling complex BRG 1 associated factor 155;Mammalian chromatin remodeling complex BRG1 associated factor 155;Rsc 8;Rsc8;SMARC C1;SMARCC 1;SMARCC1;SMRC1_HUMAN;SRG 3;SRG3;SWI 3;SWI/SNF complex 155 kDa subunit;SWI/SNF complex subunit SMARCC1;SWI/SNF related matrix associated actin dependent regulator of chromatin c1;SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1;SWI3.
Gene_symbol  Rsc8;SRG3;SWI3;BAF155;CRACC1.
Summary  The protein encoded by this gene is a member of the SWI/SNF family of proteins,whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes.The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors.[provided by RefSeq,Jul 2008]
UniPort summary  Function  Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).May stimulate the ATPase activity of the catalytic subunit of the complex.Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex,a chromatin-remodeling complex recruited by vitamin D receptor (VDR),which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex).During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state.The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A,are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF).The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth by similarity.
Application Images :  
Western blot detection of BAF155 antibody in K562,Jurkat and Hela cell lysates using BAF155 antibody (1:1000 diluted).Predicted band size:155KDa.Observed band size:155KDa.