Size  100ug
Cat code  200729
Species Cross-reactivity  H
Key Application  WB
Host  Mouse
Antibody type  Monoclonal antibody
Purified method  null
Isotype  IgG1
Molecular Weight  56kDa
Sensitivity  This antibody detects endogenous levels of TXNRD2 and does not cross-react with related proteins.
Immunogen  Purified recombinant human TXNRD2 protein fragments expressed in E.coli.
UniProt Number  Q9NNW7
GeneBank ID  NM_006440.3
Subcellular location  Mitochondrion
Formulation  ascites
Altername  Selenoprotein Z;TR-beta;Thioredoxin reductase TR3
Gene_symbol  TR; TR3; SELZ; TRXR2; TR-BETA
Summary  Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22.
UniPort summary  Function   Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.
 
  Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.
  Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.
  Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.
Application Images :  

Western blot detection of TXNRD2 in A431,U251，U2OS,LNCAP&Hela cell lysates and  using TXNRD2 antibody (1:1000 diluted). Predicted band size: 56KDa Observed band size: 56KDa