Size  100ul
Cat code  200664
Species Cross-reactivity  H
Key Application  WB
Host  Mouse
Clone Number  2H9-H6-G10
Antibody type  Monoclonal antibody
Purified method  
Isotype  IgG1
Molecular Weight  120kDa
Sensitivity  This antibody detects endogenous levels of FYB  and does not cross-react with related proteins.
Immunogen  Purified recombinant human FYB  protein fragments expressed in E.coli.
UniProt Number  O15117
GeneBank ID  NM_001465
Subcellular location  Cytoplasm. Nucleus
Formulation  Ascites containing with 0.02% sodium azide and 50% glycerol.
Altername  ADAP;Adhesion and degranulation promoting adaptor protein;FYB 120/130;Fyb;FYB-120/130;FYB_HUMAN;FYN binding protein;FYN T binding protein;FYN-binding protein;FYN-T-binding protein;p120/p130;PRO0823;SLAP 130;SLAP-130;SLAP130;SLP 76 associated phosphoprotein;SLP-76-associated phosphoprotein;SLP76 associated phosphoprotein.
Gene_symbol  ADAP;PRO0823;SLAP-130.
Summary  The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells.The encoded protein is involved in platelet activation and controls the expression of interleukin-2.Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq,Jul 2011]
UniPort summary  Function  Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells.Modulates the expression of interleukin-2 (IL-2).Involved in platelet activation.Prevents the degradation of SKAP1 and SKAP2.May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.
Application Images :  
Western blot detection of FYB antibody in 10,20 and 30ug Jurkat cell lysate using FYB antibody (1:500 diluted).Predicted band size:120KDa.Observed band size:120KDa.